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KMID : 1030220110120040194
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Journal of Korean Diabetes
2011 Volume.12 No. 4 p.194 ~ p.197
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Oral Antidiabetic Agents in Patients with Chronic Kidney Disease
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Hwang You-Chul
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Abstract
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Diabetes mellitus is the leading cause of chronic kidney disease worldwide. At present, a variety of classes of oral hypoglycemic agents are available to improve glycemic control, including newer classes of drugs such as DPP-IV inhibitors. Decreased renal function with reduced glomerular filtration rate affects the choices, dosing, and monitoring of oral hypoglycemic agents, as some agents require dose adjustments in patients with chronic kidney disease and others are entirely contraindicated. This article reviews the clinical use of oral hypoglycemic agents, focusing on pharmacokinetic properties and dosing in patients with chronic kidney disease.
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KEYWORD
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Oral administration, Hypoglycemic agents, Chronic kidney failure
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